Protein Details: Cyclic nucleotide-gated ion channel 4

Protein ID

ICDB_Pro_1386

Protein Name

Cyclic nucleotide-gated ion channel 4

Gene Name

CNGC4 HLM1 At5g54250 MDK4.7

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

694 amino acids

AlphaFoldDB

AF-Q94AS9-F1-model_v4.pdb

Function

Acts as a cyclic nucleotide-gated ion channel. Permeable to potassium and sodium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Might constitute a common downstream component of the signaling pathways leading to hypersensitive response (HR).

Sequence

MATEQEFTRASRFSRDSSSVGYYSEEDNTEEEDEEEEEMEEIEEEEEEEEEEDPRIGLTCGGRRNGSSNNNKWMMLGRILDPRSKWVREWNKVFLLVCATGLFVDPLFLYTLSVSDTCMCLLVDGWLALTVTALRSMTDLLHLWNIWIQFKIARRWPYPGGDSDGDTNKGGGTRGSTRVAPPYVKKNGFFFDLFVILPLPQVVLWVVIPSLLKRGSVTLVVSVLLVTFLFQYLPKIYHSIRHLRRNATLSGYIFGTVWWGIALNMIAYFVAAHAAGACWYLLGVQRSAKCLKEQCENTIGCDLRMLSCKEPVYYGTTVMVLDRARLAWAQNHQARSVCLDINTNYTYGAYQWTIQLVSSESRLEKILFPIFWGLMTLSTFGNLESTTEWSEVVFNIIVLTSGLLLVTMLIGNIKVFLHATTSKKQAMHLKMRNIEWWMKKRHLPIGFRQRVRNYERQRWAAMRGVDECEMVQNLPEGLRRDIKYHLCLDLVRQVPLFQHMDDLVLENICDRVKSLIFTKGETIQKEGDAVQRMLFVVRGHLQSSQLLRDGVKSCCMLGPGNFSGDELLSWCLRRPFVERLPPSSSTLVTLETTEAFGLDAEDVKYVTQHFRYTFVNEKVKRSARYYSPGWRTWAAVAVQLAWRRYKHRLTLTSLSFIRPRRPLSRCASLGEDKLRLYAAILTSPKPNPDDFDDY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 496..626; /ligand="a nucleoside 3,5-cyclic phosphate"; BINDING 565; /ligand="a nucleoside 3,5-cyclic phosphate"

Disease

Location

DOI ID

10.1046/j.1365-313x.1999.00422.x; 10.1093/dnares/5.2.131; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1104/pp.126.4.1646; 10.1105/tpc.006999

RefSeq

NP_001332114.1 [Q94AS9-1]; NP_200236.1 [Q94AS9-1]; NP_851188.1 [Q94AS9-1]